A trailblazing biologist grapples with her role in the biggest scientific discovery of our era: a cheap, easy way of rewriting genetic code, with nearly limitless promise and peril.
Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. Not, that is, until the spring of 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the new gene-editing tool CRISPR—a revolutionary new technology that she helped create—to make heritable changes in human embryos. The cheapest, simplest, most effective way of manipulating DNA ever known, CRISPR may well give us the cure to HIV, genetic diseases, and some cancers, and will help address the world’s hunger crisis. Yet even the tiniest changes to DNA could have myriad, unforeseeable consequences—to say nothing of the ethical and societal repercussions of intentionally mutating embryos to create “better” humans.
Writing with fellow researcher Samuel Sternberg, Doudna shares the thrilling story of her discovery, and passionately argues that enormous responsibility comes with the ability to rewrite the code of life. With CRISPR, she shows, we have effectively taken control of evolution. What will we do with this unfathomable power?
Jennifer Doudna, the world-famous scientist behind CRISPR, ‘one of the most monumental discoveries in biology’ (New York Times), describes its power to reshape the future of all life and warns of its use.
A handful of discoveries have changed the course of human history. This book is about the most recent and potentially the most powerful and dangerous of them all.
It is an invention that allows us to rewrite the genetic code that shapes and controls all living beings with astonishing accuracy and ease. Thanks to it, the dreams of genetic manipulation have become a stark reality: the power to cure disease and alleviate suffering, to create new sources of food and energy, as well as to re-design any species, including humans, for our own ends.
Jennifer Doudna is the co-inventor of this technology, known as CRISPR, and a scientist of worldwide renown. Writing with fellow researcher Samuel Sternberg, here she provides the definitive account of her discovery, explaining how this wondrous invention works and what it is capable of.
A Crack In Creation also asks us to consider what our new-found power means: how do we enjoy its unprecedented benefits while avoiding its equally unprecedented dangers? As Doudna argues, every member of our species is implicated in the answers to these questions. Somehow we must consider and act together.
The future of humankind – and of all life on Earth – is at stake. This book is an essential guide to the path that now lies ahead.
At the very depths of an organism, we have the life.The hitherto unbreakable mechanism of gene interaction has been snipped apart by the revolutionary technique known as CRISPR. In this book, "CRISPR Germline Alteration and Impact on Human Civilization" ,we will uncover the emerging field of genetic modification and see changes that will fashion our lifestyle in the next few years. Humans perform activity through the energy functions performed within the cells. Through simple changes, we can increase the flow of energy, just by augmenting the work function of one particular gene. We are caught up in the awesomeness of the moment, just as our fathers were, when they first witnessed the fantastic power of the steam engine. And believe me, CRISPR is very powerful indeed. To see how much the emerging technology will affect human relationship, one has to learn why bacteria and virus function in
Modifying crops and creating new pathways in medicine mark the transition which will forever change the human perception and lifestyle. For this we look at the bacteria and the way animals are related to them at the cellular level.
Read about the news of genes and the developments that have come about since the scientists cracked the CRISPR code. Learn about the leaders in the field and how they modified the scheme of things.
We learn about diseases and the changes that make it possible to deal with them. We study the many methods used to make human life more interesting and pleasurable. The different delivery methods and equipment needed to set up your own laboratory is explained.
Researchers are engaged in bringing extinct animals to life. Soon mammoths will once again roam the planet. In the process, you will also read about turning off genes that cause disease. We dwell on the prospect of bioterrorism that now seems a distinct possibility. Come join us in a different world, the world where life forms and is changed.
About the Author
Dr. Kathy Panoutsos, M.D has been involved with Healthcare, Beauty, Relationships and Fashion industry for almost a decade. She has researched fashion, healthcare and beauty in deepest sense. Due to her passion in health and well being, she has written on Yoga, Acne, Diet and Human relationships. She writes for all ages and uplifts the spirit of younger women. She loves to teach, travel and connect with all age groups. She loves to connect with readers.
A sharp-eyed exploration of the promise and peril of having children in an age of genetic tests and interventions
Is screening for disease in an embryo a humane form of family planning or a slippery slope toward eugenics? Should doctors tell you that your infant daughter is genetically predisposed to breast cancer? If tests revealed that your toddler has a genetic mutation whose significance isn’t clear, would you want to know?
In The Gene Machine, the award-winning journalist Bonnie Rochman deftly explores these hot-button questions, guiding us through the new frontier of gene technology and how it is transforming medicine, bioethics, health care, and the factors that shape a family. Rochman tells the stories of scientists working to unlock the secrets of the human genome; genetic counselors and spiritual advisers guiding mothers and fathers through life-changing choices; and, of course, parents (including Rochman herself) grappling with revelations that are sometimes joyous, sometimes heartbreaking, but always profound. She navigates the dizzying and constantly expanding array of prenatal and postnatal tests, from carrier screening to genome sequencing, while considering how access to more tests is altering perceptions of disability and changing the conversation about what sort of life is worth living and who draws the line. Along the way, she highlights the most urgent ethical quandary: Is this technology a triumph of modern medicine or a Pandora’s box of possibilities?
Propelled by human narratives and meticulously reported, The Gene Machine is both a scientific road map and a meditation on our power to shape the future. It is a book that gets to the very core of what it means to be human.
by Jim Kozubek
Would you change your genes if you could? As we confront the 'industrial revolution of the genome', the recent discoveries of Crispr-Cas9 technologies are offering, for the first time, cheap and effective methods for editing the human genome. This opens up startling new opportunities as well as significant ethical uncertainty. Tracing events across a fifty-year period, from the first gene splicing techniques to the present day, this is the story of gene editing - the science, the impact and the potential. Kozubek weaves together the fascinating stories of many of the scientists
An attempt has been made to include the following informative CRISPR Cas research News in this Booklet SERIES -2 in view of the Patency Battle going on and its application in gene editing to cure HIV, AML, Muscular Dystrophy, Cancer etc.
1.CRISPR gene editing can cause hundreds of mutations: study.
2. CRISPR Gene Editing May Cause Hundreds of Unintended Mutations in DNA
i) Potential Hazards
ii) Refining Methods
3. Researchers use gene editing to eliminate HIV infection in mice.
i) How promising is this?
4. A New Head to the Genomic Beast That is CRISPR
Will CRISPR kit be a new source of spreading resistant organism…
5. CRISPR kills HIV & EATS Zika like ‘Pac-man’, It’s next target? Cancer…
The latest? Eradicating HIV?
How CRISPR Cas13 enzyme behave like ‘Pac-man’…
6. Gene editing technique, Scientists hope will cure Cancer & all Inherited Diseases found to have dangerous flaw..
7. Another CRISPR Trial begins
8. Human ALS, iPSCs corrected through CRISPR Cas Treatment…
9. Univ. of California appeals CRISPR patent set back..
10. Gene editing could fight Muscular Dystrophy says New Research…
This book serves as an introduction to targeted genome editing, beginning with the background of this rapidly developing field and methods for generation of engineered nucleases. Applications of genome editing tools are then described in detail, in iPS cells and diverse organisms such as mice, rats, marine invertebrates, fish, frogs, and plants. Tools that are mentioned include zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and CRISPR/Cas9, all of which have received much attention in recent years as breakthrough technologies. Genome editing with engineered nucleases allows us to precisely change the target genome of living cells and is a powerful way to control functional genes. It is feasible in almost all organisms ranging from bacteria to plants and animals, as well as in cultured cells such as ES and iPS cells. Various genome modifications have proven successful, including gene knockout and knock-in experiments with targeting vectors and chromosomal editing. Genome editing technologies hold great promise for the future, for example in biomedical research, clinical medicine, and generation of crops and livestock with desirable traits. A wide range of readers will find this book interesting, and with its focus on applications in a variety of organisms and cells, the book will be valuable for life scientists in all fields.